Pellino 1 is a novel regulator of TNF and TLR signalling in human myometrial and amnion cells

R Lim; G Barker; M Lappas

Journal article

Pellino 1 is a novel regulator of TNF and TLR signalling in human myometrial and amnion cells

R Lim, G Barker, M Lappas

Journal of Reproductive Immunology | ELSEVIER IRELAND LTD | Published : 2018

DOI: 10.1016/j.jri.2018.04.003

Abstract

Preterm birth is the primary cause of neonatal deaths and morbidities. Pathological processes causally linked to preterm birth are inflammation and infection. Pellino-1 (Peli1) has previously been found to regulate the inflammatory response in non-gestational tissues in response to toll-like receptor (TLR) ligands and pro-inflammatory cytokines. The aims of this study were to determine the effect of labor on Peli1 expression in myometrium and fetal membranes, and the effect of Peli1 silencing by siRNA (siPELI1) on the production of pro-inflammatory and pro-labor mediators. The expression of Peli1 was found to be higher in myometrium and fetal membranes with term labor, compared to non-labori..

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University of Melbourne Researchers

Martha Lappas Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Associate Professor Martha Lappas is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; grant no. 1047025) and Research Fellowship from the University of Melbourne. Funding for this study was provided by the NHMRC (grant no. 1058786), University of Melbourne, Norman Beischer Medical Research Foundation and the Mercy Research Foundation.